Aromatase Inhibitors for Ovulation Induction – the Risk Is Too High Because Currently There Is Insufficient Evidence for Its Efficacy
نویسنده
چکیده
منابع مشابه
Review: aromatase inhibitors for ovulation induction.
CONTEXT For the last 40 yr, the first line of treatment for anovulation in infertile women has been clomiphene citrate (CC). CC is a safe, effective oral agent but is known to have relatively common antiestrogenic endometrial and cervical mucous side effects that could prevent pregnancy in the face of successful ovulation. In addition, there is a significant risk of multiple pregnancy with CC, ...
متن کاملPolycystic ovary syndrome: diagnosis and management of related infertility
Polycystic ovary syndrome (PCOS) is one of the most common complex and heterogeneous endocrine disorder in women with uncertain aetiology. The syndrome is associated with a wide range of symptoms and the diagnosis is based on the Rotterdam criteria. This review describes the currently available evidence regarding the therapeutic challenges raised in these women. Before any intervention is initi...
متن کاملAromatase inhibitors in stimulated IVF cycles
Aromatase inhibitors have been introduced as a new treatment modality that could challenge clomiphene citrate as an ovulation induction regiment in patients with PCOS. Although several randomized trials have been conducted regarding their use as ovulation induction agents, only few trials are available regarding their efficacy in IVF stimulated cycles. Current available evidence support that le...
متن کاملSafety of sodium-glucose co-transporter 2 inhibitors during Ramadan fasting: Evidence, perceptions and guidelines
Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new glucose-lowering therapy for T2DM with documented benefits on blood glucose, hypertension, weight reduction and long term cardiovascular benefit. They have an inherent osmotic diuretic effect and lead to some volume loss and possible dehydration. There is some concern about the safety of using SGLT2 inhibitors in Muslim type 2 diabete...
متن کاملI-35: Induction of Ovulation in Clomiphen Resistant
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder in which chronic anovulation is a common feature despite the presence of multiple micro- structures in the ovaries. A growing body of evidence has suggested that serum hyperinsulinemia and as the result hyperandrogenemia contributes to the excess ovarian androgen secretion observed in women with PCOS. The standard therapy for anovulat...
متن کامل